22^ ANNUAL
SYMPOSIUM OF THE
INTERNATIONAL CANNABINOID
RESEARCH SOCIETY
FREIBURG
JULY 22 - 27, 2012
PRELIMINARY PROGRAMME
(SUBJECT TO CHANGES)
REGISTRATION: JULY 22 nd , 2012 (16.00-19.00)
WELCOME RECEPTION: 18.30-20.00
DAY 1
Monday, July 23 rd
7.30
Breakfast
8.30
Welcome and Opening Remarks
Oral Session 1. Neurodegeneration
Chairs: David Baker and Javier Fernandez- Ruiz t,*^^
PAGE #
8.45
Daniel K. Nomura,
Tarek A. Samad
and Benjamin F. Cravatt
ENDOCANNABINOID HYDROLYSIS
GENERATES BRAIN PROSTAGLANDINS
THAT PROMOTE
NEUROINFLAMMATION
1
9.00
Scott D. Smid
and Jesper L.V. Maag
CANNABINOID LIGANDS DIRECTLY
MODIFY P- AMYLOID FIBRIL
FORMATION AND ARE VARIABLY
NEUROPROTECTIVE IN VITRO
2
9.15
Anne-Caroline Schmole,
Daniele Bano,
Pierluigi Nicotera,
Andreas Zimmer
and Judith Alferink
THE ROLE OF THE
ENDOCANNABINOID RECEPTOR
CB2 IN NEURODEGENERATION
3
9.30
Ryan Graves,
Gareth Pryce,
Michaela Egertova,
Benjamin F. Cravatt, Gavin
Giovannoni, Gregory J.
Michael, Maurice R. Elphick
and David Baker
EFFECTS OF GENETIC DELETION AND
PHARMACOLOGICAL INHIBITION OF
FATTY ACID AMIDE HYDROLASE IN
EXPERIMENTAL AUTOIMMUNE
ENCEPHALOMYELITIS
4
9.45
Nephi Stella
TARGETING CB1 RECEPTORS
AND ABHD6 TO TREAT
R6/2 MICE SYMPTOMS
5
10.00
Sara Valdeolivas,
Onintza Sagredo, Justo
Garcia de Yebenes, Julian
Romero, Roger Pertwee,
Manuel Guzman and
Javier Fernandez-Ruiz
PHYTOCANNABINOID-BASED
MEDICINES AS DISEASE-MODIFYING
AGENTS IN HUNTINGTON'S DISEASE
6
10.15
Jacqueline L. Blankman,
Jonathan Z. Long
and Benjamin F. Cravatt
GENERATION AND
CHARACTERIZATION OF
ABHD12-/- MICE, A MODEL OF THE
NEURODEGENERATIVE DISEASE
PHARC
7
10.30
Coffee Break
Oral Session 2. Metabolic Regulation / cardiovascular
Chairs-. George Kunos and Matthew Hill
11.00
George Kunos, Yossi
Tarn, Resat Cinar,
Jeih-San Liow,
Robert Innis,
Robert Chorvat
and John F. McElroy
PERIPHERAL CB1R INVERSE AGONISM
REDUCES DIET-INDUCED OBESITY BY
REVERSING LEPTIN RESISTANCE
8
11.15
Matthew N. Hill, Nicole
P. Bowles, Tiffany T. Lee
Cecilia J. Hillard
and Bruce S. McEwen
ACTIVATION OF HYPOTHALAMIC
FATTY ACID AMIDE HYDROLASE BY
LEPTIN: REGULATION OF FOOD
INTAKE AND EFFECTS OF
DIET-INDUCED OBESITY
9
11.30
Susan Krzysik-Walker,
Isabel Gonzalez-
Mariscal, Morten
Scheibye-Knudsen,
Fred Indig
and Michel Bernier
THE CANNABINOID RECEPTOR
INVERSE AGONIST AM251
ALTERS MITOCHONDRIAL
PHYSIOLOGY VIA PROTEOLYTIC
DEGRADATON OF ERRct
10
11.45
A J Wheal, M D Randall
and S E O'Sullivan
CANNABIDIOL IMPROVES IMPAIRED
ENDOTHELIAL FUNCTION IN
FEMORAL ARTERIES FROM
ZUCKER DIABETIC RATS
11
12.00
William H Hind
and Saoirse E O'Sullivan
THE EFFECTS OF ANAND AMIDE
ON PERMEABILITY IN
A CELL CULTURE MODEL
OF THE BLOOD-BRAIN BARRIER
12
12.15
Sabina Adhikary,
Hongbo Li, Mario
Skarica, Weimin Kong,
Anu Mahadevan, Doina
Ganea and Ronald Tuma
MODULATION OF INFLAMMATORY
CELL INVASION OF THE CNS
BY A CANNABINOID-2 SELECTIVE
AGONIST AFTER INJURY
13
12.30-14.00
LUNCH
Oral Session 3. psychiatric diseases / learning & memory
Chairs-. Beat Lutz and Sara Jane Ward
14.00
Eti Ganon-Elazar
and Irit Akirav
CANNABINOIDS PREVENT THE
DEVELOPMENT OF POST-TRAUMA
SYMPTOMS IN A RAT MODEL OF PTSD
14
14.15
Ozge Gunduz-Cinar, Caitlin
M Schaapveld, Kathryn P.
MacPherson, Resat Cinar,
Joyonna Gamble-
George, Karen Sugden,
Benjamin Williams,
Grzegorz Godlewski, Teniel
S Ramikie, Adam X. Gorka,
Shakiru O. Alapafuja,
Spyros P. Nikas,
Alexandras Makriyannis,
Richie Poulton, Sachin
Patel, Ahmad R. Hariri,
Avshalom Caspi, Terrie E.
Moffitt, George Kunos
and Andrew Holmes
ANAND AMIDE IN AMYGDALA-
MEDIATED FEAR EXTINCTION, THREAT
PROCESSING AND STRESS-REACTIVITY:
A TRANSLATIONAL STUDY
15
14.30
Ilya Reznik
MEDICAL CANNABIS/MARIJUANA USE
IN POST-TRAUMATIC STRESS
DISORDER: A LONGITUDINAL
FOLLOW-UP STUDY
16
14.45
Moriah Iverson
and Cecilia J. Hillard
ANXIOGENIC-LIKE EFFECT OF
THC is lost IN MICE LACKING
BETA-ARRESTIN-2: EVIDENCE
FOR SEX-DEPENDENT EFFECTS
17
15.00
Daniela Hauer, Piray
Atsak, Raquel V. Fornari,
Patrizia Campolongo,
Gustav Schelling
and Benno Roozendaal
T'TV [ T ~*\ / — X / — • A TV TTV T A 11 1 \ [ / — "\ I T ~\
ENDOCANNABINOID-
GLUCOCORTICOID INTERACTION IN
THE BASOLATERAL AMYGDALA
DURING MEMORY CONSOLIDATION
18
15.15
Maria Morena,
Viviana Trezza,
Sergio Scaccianoce,
Alessandro Pasquale,
Vincenzo Cuomo,
Gustav Schelling,
Benno Roozendaal
and Patrizia
Campolongo
CANNABINOIDS MODULATION OF
OBJECT RECOGNITION MEMORY IN
RATS: INVOLVEMENT OF THE
GLUCOCORTICOID SYSTEM
19
15.30
Xiang-Qun Xie, Rentian
Feng, Peng Yang, Junpei
Teramachi, Qin Tong,
Lirong Wang, Zhaojun
Xie, Kyaw Myint,
Noriyoshi Kurihara
and David G. Roodman
CANNABINOID RECEPTOR CB2.
A NEW DRUG TARGET FOR
MULTIPLE MYELOMA INTERVENTION
20
15.45-17.45
Poster Session l
Coffee
PI
18.00
Presidential Plenary Speaker
"Planning research for the next half a century"
RAPHAEL MECHOULAM, PH.D.
Institute for Drug Research
Hebrew University of Jerusalem
Day 2
Tuesday, July 24 th
7.30
Breakfast
ORAL SESSION 4. RECEPTOR SIGNALING
Chairs: Heather Bradshaw and MaryAbood
8.30
Mark Bauer,
Andrea Chicca, Stefanie
Hofer-Reyes, Marco
Tamborrini, David Eisen,
Oliver Poetz,
Gerd Pluschke
and Jiirg Gertsch
IDENTIFICATION OF A FAMILY OF
PEPTIDE ENDOCANNABINOIDS
(PEPCANS): EVIDENCE FOR
ALLOSTERIC MODULATION
OF CB1 RECEPTORS
21
8.45
Maria Grazia Cascio,
Daniele Bolognini
and Roger G. Pertwee
Irlt LDl Ktii„til 1UK ALLU5 1 EKrC
MODULATOR, ORG 27569,
HAS DIFFERENT EFFECTS ON THE
POTENCIES WITH WHICH CP55940,
O-2050 AND SR141716A DISPLACE
[3H]CP55940 OR [3H]SR141716A
FROM MOUSE BRAIN CB1 RECEPTORS
22
9.00
Derek M. Shore, Dow P.
Hurst, Herb Seltzman,
Gemma Baillie,
Ruth Ross, Jahan P.
Marcu, Mary Abood
and Patricia H. Reggio
IDENTIFICATION OF THE ORG27569
BINDING SITE AT THE CB1 RECEPTOR:
IMPORTANCE OF K3.28 INTERACTION
TO THE ORG27569 EFFECT ON BASAL
SIGNALING
23
9.15
Michelle Glass,
Erin Cawston, Courtney
Breen, William Redmond
and Mark Connor
ALLOSTERIC MODULATION OF
HUMAN CB1 RECEPTORS
24
9.30
Eugen Brailoiu,
G. Cristina Brailiou,
Elena Deliu,
Haleli Sharir,
Pingwei Zhao
and Mary E. Abood
FUNCTIONAL INTRACELLULAR
CANNABINOID RECEPTORS
25
9.45
Lawrence C. Blume,
Caroline E. Bass,
George D. Dalton,
Dana E. Selley
and Allyn C. Howlett
CANNABINOID RECEPTOR
INTERACTING PROTEIN (CRIP1A)
MODULATES CB1 RECEPTOR
TRAFFICKING, ACTIVITY
AND SIGNALING
26
10.00
1\ a Idol la 1_ Vji 111 Lacy,
Duneeshya Gunasekara,
Erin Cawston,
Catherine E Goodfellow
and Michelle Glass
UNUSUAL TRAFFICKING OF
CANNABINOID RECEPTOR 2:
AGONIST-INDUCED UPREGULATION
OF SURFACE RECEPTORS
27
10.15
Heather B. Bradshaw,
Siham Raboune
and Jordyn M. Stuart
71 MDVFT NT ATYT AMinPS
INCLUDING N-DOCOSAHEXEANOYL
ETHANOLAMINE, HAVE ACTIVITY AT
TRPV1-4 THE PUTATIVE IONOTROPIC
CANNABINOID RECEPTORS
28
10.30
Christopher J. Fowler,
Peter Hammarsten and
Mariateresa Cipriano
ASSOCIATION BETWEEN TUMOUR
PAKT AND CB1 RECEPTOR EXPRESSION
IN PROSTATE CANCER
29
10.45
Coffee Break
Oral Session 5. gastrointestinal regulation
Chairs-. Steven Kinsey and Mario van der Stelt
11.00
Steven G. Kinsey,
Erica C. Cole
and Aron H. Lichtman
REMARKABLE POTENCY OF A'-THC IN
BLOCKING GASTRIC HEMORRHAGES
CAUSED BY CYCLOOXYGENASE
INHIBITION IN MICE
30
11.15
Mohammad Bashashati,
Yasmin Nasser, Catherine
M. Keenan, Winnie Ho,
Fabiana Piscitelli, Giorgio
Ortar, Ken Mackie,
Martin A. Storr,
Vincenzo Di Marzo
and Keith A. Sharkey
THE LOCALIZATION AND FUNCTION
OF DIACYLGLYCEROL
LIPASE (DAGL) IN THE
GASTROINTESTINAL TRACT
31
11.30
Luan Koay, Rachael
Rigby and Karen Wright
CANNABIDIOL INDUCES NON-
CANONICAL AUTOPHAGY
32
11.45
kang Tsou Memorial Lecture
"DO DIFFERENTIATED NEURONS MIGRATE?"
Michael Frotscher, M.D.
Institute for Structural Neurobiology
Center for Molecular Neurobiology (ZMNH)
Universitatsklinikum Hamburg-Eppendorf (LIKE)
Hamburg
12.45-14.00
NIDA Trainee Lunch and Learn
"Cannabinoid Pharmaceutics:
Historical Influences on Millennial Research"
John McPartland and Allyn Howlett
12.45-14.00
Lunch
Oral Session 6. PAIN
Chairs-. Katarzyna Starowicz and Andrea Hohmann
14.00
Katarzyna Starowicz,
Wioletta Makuch,
Michal Korostynski,
Michal Slezak,
Magdalena Zychowska,
Stefania Petrosino,
Luciano De Petrocellis,
Luigia Cristino, Barbara
Przewlocka
and Vincenzo Di Marzo
full inhibition of spinal fatty
acid amide hydrolase in
neuropathic rats leads to trpvi-
mediated analgesic effects via
remodeling of the
endocannabinoid system
33
14.15
K. Starowicz, N. Malek,
M. Mrugala, W. Makuch,
Francesca Comelli,
G. Ortar, E. Morera,
B. Costa, B. Przewlocka
and V. Di Marzo
omdm198, a compound
targeting both trpvi and fatty
acid amide hydrolase: a new
pain management strategy in
osteoarthritis?
34
14.30
James P Pearson,
Sylvie Bernier, Carlotta
Jackson, James D
Wakefield, Kristie A
Sykes, Elaine Liong,
Galen Carey, Robert W
Busby, Mark G Currie,
Aron H Lichtman,
G Todd Milne
and Albert T Profy
ORAL TREATMENT WITH THE
SELECTIVE FAAH INHIBITOR
MM-433593 RELIEVES THERMAL
HYPERALGESIA INDUCED
BY E. COLI LIPOPOLYSACCHARIDE
IN C57BLACK6/J MICE
VIA CANNABINOID CB1 RECEPTOR
35
14.45
Andrew J. Kwilasz,
Aron Lichtman
and Steve Negus
THE FAAH INHIBITORS PF3845 AND
URB597 PRODUCE DISTINCT EFFECTS
ON ACUTE PAIN-STIMULATED AND
PAIN-DEPRESSED BEHAVIOR IN RATS
36
15.00
Mauro Dionisi,
Cataldo Martucci,
Glauco Tarozzo,
Rosalia Bertorelli,
Angelo Reggiani
and Daniele Piomelli
A NOVEL NAAA INHIBITOR
REVERSED UVB-INDUCED
INFLAMMATORY RESPONSE
BOTH IN VITRO AND IN VIVO
37
15.15
Bogna M. Ignatowska-
Jankowska, Sudeshna
Gosh, Micah J. Niphakis,
Scott O Neal,
D. Matthew Walentiny,
Jenny L. Wiley,
Benjamin F. Cravatt,
and Aron H. Lichtman
THE SELECTIVE MONOACYLGLYCEROL
LIPASE INHIBITOR KML29 PRODUCES
ANTINOCICEPTION IN THE ABSENCE
OF CANNABIMIMETIC EFFECTS
38
15.30
Herbert H. Seltzman,
Craig Shiner, Erin Hirt,
Anne F. Gilliam,
Rangan Maitra,
Rodney W. Snyder,
Yatendra Mulpuri and
Igor Spigelman
PERIPHERALLY RESTRICTED
CB1 AGONISTS FOR
TREATMENT OF NEUROPATHIC PAIN
39
15.45
James Burston,
Devi Sagar, Stephen
Woodhams, Gareth
Hathway, Emma King,
Andrew Bennett,
David Kendall
and Victoria Chapman
EVIDENCE THAT CANNABINOID CB2
RECEPTORS PLAY A NOVEL ROLE IN
THE MODULATION OF SPINAL
HYPERSENSITIVITY AND PAIN
BEHAVIOUR IN THE RAT MIA MODEL
OF OSTEOARTHRITIS
40
16.00-18.00
POSTER SESSION 2
Coffee
P2
ORAL SESSION 7. PHYTOCANNABINOIDS
Chairs: Mahmoud ElSohlyand Barbara Costa
18.00
Jonathan E. Page,
Harm van Bakel, Jake Stout
and Timothy R. Hughes
GENOMIC ANALYSIS OF
PHYTOCANNABINOID
BIOSYNTHESIS IN
CANNABIS SATIVA L.
41
18.15
Michelle Sexton,
Eiron Cudaback,
Rehab A. Abdullah
and Nephi Stella
CANNABIS USE AS A
COMPLEMENTARY
ALTERNATIVE MEDICINE IN
MULTIPLE SCLEROSIS:
EFFECTS ON SOME IMMUNE
PARAMETERS
42
18.30
Daniele Bolognini,
Erin M. Rock,
Maria Grazia Cascio,
Linda Parker
and Roger G. Pertwee
C ANNABEL) FOLIC ACID
BEHAVES AS A HIGHLY
POTENT ENHANCER OF
C I I T 1 A T)T ." 'T |yi7 \ T )
5-rlt tA KbCbl 1UK
ACTIVATION BOTH IN VITRO
AND IN VIVO
43
18.45
Francesca Comelli,
Giulia Filippi,
Elena Papaleo,
Luca De Gioia,
Roger Pertwee
and Barbara Costa
EVIDENCE THAT THE
PHYTOCANNABINOID
CANNABIGEROL CAN
INDUCE ANTINOCICEPTION
BY ACTIVATING
a2-ADRENORECEPTORS: A
COMPUTATIONAL AND A
PHARMACOLOGICAL STUDY
44
19.00
Istvan Ujvary, Alessia Ligresti,
Rosaria Villano,
Marco Allara
and Vincenzo Di Marzo
YANGONIN, A
KAVALACTONE FROM
PIPER METHYSTICUM,
IS A NOVEL CB1
RECEPTOR LIGAND
45
Day 3
Wednesday, July 25 th
7.30
Breakfast
Oral Session 8. Drug addiction
Chairs-. Tiziana Rubino and Iain McGregor
8.30
Ryan Vandrey,
Maxine L. Stitzer,
Miriam Z. Mintzer,
Marilyn A. Huestis,
Jeannie A. Murray
and Dayong Lee
THE DOSE EFFECTS OF
DRONABINOL (ORAL THC)
IN HEAVY CANNABIS USERS
46
8.45
Margaret Haney, Gillinder
Bedi, Ziva D. Cooper,
and Richard W. Foltin
PREDICTORS OF MARIJUANA
RELAPSE: ROBUST IMPACT OF
CIGARETTE SMOKING
47
9.00
Matthew W. Buczynski,
Tlham Y Poll's
and Loren H. Parsons
THE VOLITIONAL NATURE OF
NICOTINE EXPOSURE
DIFFERENTIALLY ALTERS
ANANDAMIDE AND
OLEOYLETHANOLAMIDE LEVELS IN
THE VENTRAL TEGMENTAL AREA
48
9.15
Iain S. McGregor, Kirily
Keats, Alex Wong,
Kieron Rooney and
Jonathon C. Arnold
A 9 -THC "REINTOXICATION" EFFECTS
IN RATS AND HUMANS
49
9.30
Brian F. Thomas, Poonam
G. Pande, Richard C.
Daw, Kenneth H. Davis,
Jenny L. Wiley
and Megan E. Grabenauer
ANALYSIS OF SMOKE
COMPOSITION FROM PRODUCTS
CONTAINING SYNTHETIC
CANNABINOIDS
50
9.45
Jenny L. Wiley,
Timothy W. Lefever
and Julie A. Marusich
PHARMACOLOGICAL PROFILE OF
ABUSED INDOLE-DERIVED
CANNABINOIDS CONTAINED IN
'HERBAL INCENSE' IN MICE
51
10.00
Miriam Schneider,
Chris M. Friemel
and Andreas Zimmer
HEDONIC REWARD PROCESSING
IS ATTENUATED IN CB1 RECEPTOR
KNOCKOUT MICE
52
10.15
McMahon LR, Hruba L,
Kinsey SG, O'Neal ST,
Cravatt BF
and Lichtman AH
COMBINED EFFECTS OF A
MONOACYLGLYCEROL LIPASE AND
FATTY ACID AMIDE HYDROLASE
INHIBITOR IN MICE DISCRIMINATING
A 9 -TETRAHYDROCANNABINOL
53
10.30
Zheng-Xiong Xi, Xiao-
Qing Peng, Xia Li, Hong-
Ju Yang, Jie Li
and Eliot L. Gardner
CANNABINOID CB2 RECEPTORS
MODULATE COCAINE
SELF- ADMINISTRATION IN RATS
54
10.45-12:45
POSTER SESSION 3
Coffee
P3
12.45
Lunch
14.00
Excursion to the Black forest
NOTES:
Day 4
Thursday, July 26 th
7.30
Breakfast
8.20
NIDA Symposium
Role of Cannabinoid System
in Nicotine Addiction
ORGANIZERS: VlSHNUDUTT PUROHIT AND RAO RAPAKA
DISCUSSANTS: BEN CRAVATT AND ARON LlCHTMAN
8.30
Sherry Niessen
Scripps Research Institute
La Jolla, CA USA
PROTEOMICS OF
NICOTINE-DEPENDENT BRAIN
8.55
Daniele Piomelli
University of California
Irvine, CA USA
FAAH INHIBITORS AS POTENTIAL
LEADS FOR SMOKING CESSATION
9.20
Aron Lichtman
Virginia Commonwealth University
Richmond, VA USA
MODULATING NICOTINE REWARD
AND DEPENDENCE THROUGH THE
ENDOGENOUS CANNABINOID SYSTEM
9.45
Rafael Maldonado
Universitat Pompeu Fabra
Barcelona, Spain
TARGETING THE CB1 RECEPTOR TO
TREAT NICOTINE ADDICTION
10.10
COMMENTARY AND DISCUSSION
10.35
Coffee Break
11.00
YOUNG INVESTIGATOR AWARDEE SPEAKER
"Interplay of endocannabinoids and plant derived
cannabinoids with inflammation, oxidative stress and cell
death: implications for tissue injury and protection"
PAL PACHER, M.D., PH.D.
Laboratory of Physiological Studies
National Institute on Alcohol Abuse and Alcoholism,
Bethesda,MD USA
12.00
Lunch
Oral Session 9. endocannabinoid synthesis / catabolism
Chairs: Daniel Nomura and Natsuo Ueda
13.15
Torn Uyama, Natsuki
Ikematsu, Manami Inoue,
Naoki Shinohara, Xing-
Hua Jin, Kazuhito Tsuboi,
Takeharu Tonai,
Akira Tokumura
and Natsuo Ueda
GENERATION OF N-
ACYLPHOSPHATIDYLETHANOLAMINE
BY MEMBERS OF PHOSPHOLIPASE
A/ACYLTRANSFERASE (PLA/AT)
FAMILY
55
13.30
Bela Szabo
and Mario Lederer
CALCIUM RELEASE FROM THE
ENDOPLASMIC RETICULUM
CONTRIBUTES TO TRIGGERING
ENDOCANNABINOID PRODUCTION
IN CEREBELLAR PURKINJE CELLS
56
13.45
Nolan D. Hartley,
Daniel J. Hermanson,
Lawrence J. Marnett
and Sachin Patel
SUBSTRATE SELECTIVE INHIBITION
OF COX-2 AS A NOVEL STRATEGY
FOR IN VIVO ENDOCANNABINOID
AUGMENTATION
57
14.00
Melissa V. Turman,
Daniel Hermanson,
Jeffery J. Prusakiewicz,
Philip J. Kingsley,
Andrews S. Felts, Kelsey
C. Duggan, Sachin Patel
and Lawrence J. Marnett
ACETAMINOPHEN AND ITS
METABOLITES, 4-AMINOPHENOL AND
AM-404, ARE SUBSTRATE-SELECTIVE
INHIBITORS OF ENDOCANNABINOID
OXYGENATION BY
CYCLOOXYGENASE-2
58
14.15
KwanNok Leung,
Stephanie Vivieca, Jing
Sun, Sherrye T. Glaser,
Dale G. Deutsch
and Martin Kaczocha
FLAT IS NOT AN INTRACELLULAR
ANAND AMIDE TRANSPORTER
59
14.30
Attila Olah, Balazs I.
Toth, Attila G. Szollosi,
Lidia Ambrus,
Christos C. Zouboulis
and Tamas Biro
FATTY ACID AMIDE HYDROLASE
INHIBITORS EXERT COMPLEX
ANTI-ACNE ACTIONS IN
HUMAN SEBOCYTES
60
14.45
Julian Romero, Carolyn
Tanner, Richard Lennertz,
Amanda Smith,
Cheryl L. Stucky
and Cecilia J. Hillard
T ONFd-TFRM CHANFCIFS TM FATTY ACTD
AMIDE HYDROLASE KNOCKOUT MICE:
INVOLVEMENT OF THE TRANSIENT
RECEPTOR POTENTIAL
VANILLOID 1 RECEPTOR
61
15.00
Lalita D. Shrestha
and Cecilia J. Hillard
REGULATION OF
MONOACYLGLYCEROL LIPASE
FUNCTION BY PHOSPHORYLATION
62
15.15
Coffee Break
15.45
William T. Berger,
Brian P. Ralph, Jing Sun,
Martin Kaczocha, Trent E.
Balius, Robert C. Rizzo,
Iwao Ojima
and Dale G. Deutsch
VIRTUAL SCREENING FOR INHIBITORS
OF THE AN AND AMIDE TRANSPORTER
(FATTY ACID BINDING PROTEINS)
63
16.00
Carmen Vazquez, Marta
Moreno, Lourdes Ruiz-
Valdepeiias, Elena Tomas,
Samuel Ruiz de Martin,
Rosa Maria Tolon
and Julian Romero
FATTY ACID AMIDE HYDROLASE
DELETION POTENTIATES IN VIVO
GLIAL ACTIVITY IN RESPONSE TO
ACUTE BRAIN INJURY
64
Oral Session 10. in Memoriam of ester Fride:
endocannabinoids and development
Chairs: Sharon AnavlGofferand Mauro Maccarrone
16.15
OPENING REMARKS
16.25
Mauro Maccarrone,
Mariangela Pucci, Sara Di
Siena, Daniele Di
Giacomo, Valentina
Pirazzi, Raffaele Geremia
and Paola Grimaldi
REGULATION OF THE FAAH GENE
BY ESTROGEN ENGAGES HISTONE
DEMETHYLASE LSD1
65
16.40
Tiziana Rubino, Pamela
Prini, Erica Zamberletti,
Simona Speziali
and Daniela Parolaro
THE ENDOCANNABINOID SYSTEM
PLAYS A ROLE IN NEURONAL
REFINEMENT OCCURRING IN THE
ADOLESCENT PREFRONTAL CORTEX
66
16.55
Chris M. Friemel,
Rainer Spanagel
and Miriam Schneider
ACUTE AND CHRONIC CANNABINOID
TREATMENT DIFFERENTLY AFFECT
ETHANOL INTAKE IN PUBERTAL
AND ADULT RATS
67
17.10
Sangeetha Gajendra,
Madeleine Oudin,
Patrick Doherty
and Giovanna Lalli
A CANNABINOID-RALA SIGNALLING
PATHWAY CONTROLLING NEURAL
PROGENITOR MIGRATION
68
17.25
Sharon Anavi-Goffer,
Merav Hajby, Dorian
Solomon, Alex Naftaly,
Ont Karmmsky, Raphael
Mechoulam, Iain R.
Greig, Ruth A. Ross,
Peter McCaffery
and Kirsty Shearer
ALTERATIONS IN CANNABINOID
SIGNALLING CONTRIBUTE
TO ADHD-LIKE SYMPTOMS
AT ADULTHOOD
69
17.40-18.40
ICRS BUSINESS MEETING
19.00-23.00
ICRS BANQUET
DEPARTURE: FRIDAY, JULY 27™
POSTER SESSION 1: TOPICS A - D
DAY 1, MONDAY, JULY 23 rd : 15:45 - 17:45
TOPIC A NEURODEGENERATION
Robert B Laprairie,
Melanie E M Kelly
and Eileen M Denovan-Wright
TYPE 1 CANNABINOID RECEPTOR (CBl)-MEDIATED
INDUCTION OF CB1 EXPRESSION IN CELLULAR MODELS
OF HUNTINGTON'S DISEASE
Pl-1
Hamad Al-Harbi,
David A Kendall
and Stephen PH Alexander
EFFECTS OF CANNABIDIOL AND HU210 ON VIABILITY
OF SH-SY5Y HUMAN NEUROBLASTOMA CELLS
Pl-2
Pazos MR, Mohamed N,
Martinez-Pinilla E, Ceprian M,
Lafuente H, Santos M, Romero J,
Alvarez FJ, Franco R, Hillard C
and Martinez-Orgado J.
INVOLVEMENT OF CB2 AND 5HT1A RECEPTORS IN
CANNABIDIOL-INDUCED NEUROPROTECTION AFTER
HYPOXIA-ISCHEMIA IN NEWBORN PIGS
Pl-3
Ceprian M, Pazos MR,
Mohammed N, Santos M,
Mechoulam R
and Martinez-Orgado J.
THE CB2 AGONIST HU308 REDUCES BRAIN
HYPOXIC-ISCHEMIC DAMAGE IN NEWBORN RATS
Pl-4
Pazos MR, Mohammed N,
Ceprian M, Santos M
and Martinez-Orgado J.
NEUROPROLIFERATIVE EFFECT OF
CANNABIDIOL ADMINISTRATION TO NEWBORN
RATS AFTER HYPOXIA-ISCHEMIA
Pl-5
Sonja Kallendrusch, Faramarz
Dehghani and Marco Koch
THE GPR55 LIGAND L-01-LYSOPHOSPHATIDYLINOSITOL
(LPI) EXERTS NEUROPROTECTIVE EFFECTS AFTER
EXCITOTOXIC LESION IN VITRO
Pl-6
Carmen Vazquez, Marta
Moreno, Lourdes Ruiz-
Valdepenas, Samuel Ruiz de
Martin, Elena Tomas, Rosa Maria
Tolon and Julian Romero
CANNABIDIOL POTENTIATES IN VIVO MICROGLIAL
ACTIVITY IN RESPONSE TO ACUTE BRAIN INJURY
Pl-7
Balapal S. Basavarajappa,
Madhu Shivakumar,
Delphine Psychoyos,
Shan Xie
and Shivakumar Subbanna
AEA/CB1R SIGNALING CONTRIBUTES TO FETAL
ALCOHOL SPECTRUM DISORDER
Pl-8
Iryna A. Khasabova, Matt Tracy,
Natalya Burlakova, Sergey
G.Khasabov, Catherine Harding-
Rose, Donald A. Simone
and Virginia S. Seybold
FACILITATION OF ANANDAMIDE SIGNALING REDUCES
NEUROTOXICITY PRODUCED BY CISPLATIN
Pl-9
Marie-Louise Zeissler, C. Oliver
Hanemann, John P. Zajicek
and Camille B. Carroll
THE FAAH INHIBITOR URB597 IS PROTECTIVE
AGAINST MPP+ IN A CELL CULTURE
MODEL OF PARKINSON'S DISEASE
Pl-10
Alex Straiker, Meggie D Beazley,
Sherry Shu- Jung Hu,
Suresh Viswanathan,
Heather Bradshaw
and Melanie EM Kelly
EVIDENCE THAT A FUNCTIONAL GPR18-BASED
SIGNALING SYSTEM IN THE ANTERIOR MURINE EYE
MODULATES INTRAOCULAR PRESSURE
PM1
John Zajicek
WHAT DO RESULTS FROM THE CANNABINOID USE IN
PROGRESSIVE INFLAMMATORY BRAIN DISEASE
(CUPID) TRIAL TELL US ABOUT THE POTENTIAL
OF CANNABINOIDS FOR NEUROPROTECTION?
PM2
Mauro Maccarrone, Valerio
Chiurchiu, Maria Teresa
Cencioni, Elisa Bisicchia, Marco
De Bardi, Claudio Gasperini,
Diego Centonze
and Luca Battistini
AN AND AMIDE HAS DISTINCT EFFECTS
ON HUMAN MYELOID AND PLASMACYTOID
DENDRITIC CELLS IN MULTIPLE SCLEROSIS
PM3
TOPIC B. METABOLIC REGULATION / CARDIOVASCULAR
Paul A.K.E. Gyimah
and W. -S. Vanessa Ho
EFFECTS OF HIGH GLUCOSE ON THE
VASCULAR ACTION OF ANAND AMIDE
IN YOUNGER AND OLDER RATS
PM4
Lucie Geurts, Nathalie M.
Delzenne and Patrice D. Cani
CHRONIC ENDOCANNABINOID SYSTEM ACTIVATION
AND METABOLIC ENDOTOXEMIA DIFFERENTIALLY
AFFECT THE ONSET OF GLUCOSE INTOLERANCE AND
INFLAMMATION IN HIGH-FAT DIET-INDUCED
METABOLIC ALTERATIONS
P145
Emmelie Bjorklund, Anders E.
Blomqvist, Daniele Piomelli,
Giovanni Bottegoni
and Christopher J. Fowler
FUNCTIONAL MEASUREMENT OF FLAT-SENSITIVE
ANANDAMIDE UPTAKE INTO THREE RAT CELL LINES
PM6
Li-Sheng Jiang, Xiao-Jin Huang,
Ying-Min Chen and Ben He
ROLE AND MECHANISM OF CANNABINOID CB2
RECEPTOR ACTIVATION IN REGULATING THE
EFFEROCYTOSIS FUNCTION OF MACROPHAGE
PM7
Tiziana Bisogno, Anu
Mahadevan, Roberto Coccurello,
Jae Won Chang, Marco Allara,
Yugang Chen, Aron Lichtman,
Benjamin F. Cravatt, Anna Moles
and Vincenzo Di Marzo
DESIGN, SYNTHESIS AND PHARMACOLOGICAL
ACTIVITY OF O-7460, A NOVEL FLUOROPHOSPHONATE
INHIBITOR OF THE BIOSYNTHESIS
OF 2-ARACHIDONOYL-GLYCEROL
PM8
Edgar Soria-Gomez,
Luigi Bellocchio, Mounir
Bendahmane, Leire Reguero,
Astrid Cannich, Elodie Richard,
Pedro Grandes, Hirac Gurden
and Giovanni Marsicano
CANNABINOID TYPE-1 (CBl)-DEPENDENT REGULATION
OF FOOD INTAKE IN THE OLFACTORY BULB
PM9
A J Wheal, S E O'Sullivan
and M D Randall
ACUTE VASCULAR EFFECTS OF ENDOCANNABINOIDS
IN THORACIC AORTAE FROM ZUCKER DIABETIC RATS
Pl-20
Barbara Malinowska, Emilia
Grz^da and Eberhard Schlicker
INVOLVEMENT OF THE HYPOTHALAMIC
PARAVENTRICULAR NUCLEUS IN THE
PRESSOR EFFECT OF THE CANNABINOID
RECEPTOR AGONIST CP55940
Pl-21
Cristoforo Silvestri, Andrea
Martella, Fabiana Piscitelli,
Neil Poloso, David Woodward
and Vincenzo Di Marzo
THE PROSTAMIDE ANALOGUE BIMATOPROST
INHIBITS ADIPOGENESIS
Pl-22
William H Hind
and Saoirse E O'Sullivan
CANNABIDIOL PROTECTS THE BLOOD-BRAIN BARRIER
AGAINST INCREASED PERMEABILITY FOLLOWING
OXYGEN -GLUCOSE DEPRIVATION
Pl-23
C P Stanley
and Saoirse E O'Sullivan
2-AG RESPONSES ARE BLUNTED IN PATIENTS WITH
CARDIOVASCULAR DISEASE AND CARDIOVASCULAR
DISEASE RISK FACTORS
PI -24
C P Stanley
and Saoirse E O'Sullivan
CANNABIDIOL INDUCED VASORELAXATION
OF HUMAN MESENTERIC ARTERIES IS MEDIATED
BY THE ENDOTHELIUM, CB1 AND TRPV1
Pl-25
Lysanne Campeau, Claudius
Fullhase, Allyn Howlett
and Karl-Erik Andersson
CYSTOMETRIC EFFECTS OF SPINAL CANNABINOID
RECEPTOR ACTIVATION IN NORMAL RATS
Pl-26
Lysanne Campeau, Claudius
Fullhase, Allyn Howlett
and Karl-Erik Andersson
ROLE OF TRPV1 RECEPTORS IN THE SPINAL
EFFECTS OF N-ACYL-ETHANOLAMINE ON
THE MICTURITION IN THE NORMAL RAT
Pl-27
Raj Kamal Srivastava
and Beat Lutz
DYSREGULATION OF HYPOTHALAMIC-PITUITARY-
ADRENAL AXIS IN MICE LACKING CB1 RECEPTOR IN
ADRENERGIC AND NORADRENERGIC NEURONS
Pl-28
Paolo Lazari
and Andrea Mastinu
NOVEL SELECTIVE CB1 ANTAGONIST
AGENT WITH ANTI-OBESITY ACTIVITY
Pl-29
Topic C. psychiatric diseases / learning & memory
Sabrina F. Lisboa,
Felipe V. Gomes
and Francisco S. Guimaraes
CANNABIDIOL ATTENUATES ISOLATION-
INDUCED AGGRESSION IN MICE BY
ACTIVATION OF 5-HT1A RECEPTORS
Pl-30
Fabricio A. Moreira, Luciano R.
Vilela, Daniel C. Medeiros,
Gustavo H. Rezende, Antonio C.
Oliveira and Marcio F. Moraes
EFFECTS OF CANNABINOIDS AND ENDOCANNABINOID-
HYDROLYSIS INHIBITION ON PENTYLENETETRAZOLE-
INDUCED SEIZURES AND
ELECTROENCEPHALOGRAPHIC ACTIVITY
Pl-31
Martin A. Sticht
and Linda A. Parker
THE ROLE OF INTRA- VISCERAL INSULAR CORTEX 2AG
IN CONDITIONED NAUSEA-LIKE BEHAVIOR IN RATS
Pl-32
Anja A. Goepfrich , Matthias
Klugmann, Thomas Enkel
and Miriam Schneider
ADULT RATS OVEREXPRESSING THE CB1 RECEPTOR IN
THE MPFC DISPLAY ALTERED EMOTIONAL BEHAVIOR
AND PMPAIRED EXTINCTION OF FEAR MEMORY
Pl-33
Ryan J. McLaughlin,
Matthew N. Hill,
Tiffany Lee, Jay Schulkin,
Cecilia J. Hillard
and Bruce S. McEwen
CRH MEDIATES THE EFFECTS OF GLUCOCORTICOIDS ON
ENDOCANNABINOID SIGNALING IN THE AMYGDALA
Pl-34
Daniela Hauer, Hannah Gola,
Patrizia Campolongo,
Iris-Tatjana Kolassa
and Gustav Schelling
PLASMA LEVELS OF ENDOCANNABINOIDS
AND RELATED PRIMARY FATTY ACID
AMIDES ARE INCREASED IN PATIENTS
WITH POST-TRAUMATIC STRESS DISORDER
Pl-35
Tiffany T.-Y. Lee, Matthew N.
Hill, Sarah B. Filipski
and Bruce S. McEwen
MORPHOLOGICAL AND BEHAVIOURAL EVIDENCE
FOR IMPAIRED PREFRONTAL CORTICAL FUNCTION
IN FEMALE CB1 RECEPTOR DEFICIENT MICE
Pl-36
Vincenzo Micale, Fabricio A.
Pamplona, Alexandra Sulcova,
Filippo Drago
and Carsten T. Wotjak
THE MODULATION OF THE ENDOCANNABINOID
SIGNALING MEDIATES THE EXTINCTION
OF AVOIDANCE BEHAVIOR BY CONTROLLING
SAFETY LEARNING
Pl-37
Irena Smaga, Aneta
Piwowarczyk, Beata Bystrowska
and Malgorzata Filip
CriAJNGhblJN itih LEVEL Ur EJN DUC, AN IN AdIJN UlDb
AND ENDOCANNABINOID-LIKE MOLECULES
AFTER ACUTE AND REPEATED ADMINISTRATION
OF IMIPRAMINE AND N- ACETYLCYSTEINE IN
DIFFERENT RAT BRAIN STRUCTURES
Pl-38
Hila Abush and Irit Akirav
CANNABINOIDS AMELIORATE IMPAIRMENTS
INDUCED BY CHRONIC STRESS TO SYNAPTIC
PLASTICITY AND SHORT-TERM MEMORY
Pl-39
Amir Segev and Irit Akirav
CANNABINOID AND GLUCOCORTICOID RECEPTORS
IN THE AMYGDALA MODULATE THE STRESS-INDUCED
IMPAIRMENT OF LTP IN THE HIPPOCAMPAL-
ACCUMBENS PATHWAY
PI -40
Teniel S. Ramikie
CllLU i^aV-l L±l L J- CI LCI
ENDOCANNABINOID-MEDIATED SYNAPTIC
DEPRESSION IN THE CENTRAL AMYGDALA:
CHOLINERGIC-CANNABINOID INTERACTIONS
Pl-41
Felicha T. Candelaria-Cook
and Derek A. Hamilton
CHRONIC WIN 55,212-2 EXPOSURE AND DENTATE
DENDRITIC MORPHOLOGY IN ADULT RATS
PI -42
Robert E. Hampson,
Cheryl Ann Sexton,
John Sesay,
Anushka Goonawardena
and Sam A. Deadwyler
CANNABINOIDS ALTER REVERSAL
OF BEHAVIORAL CONTINGENCY
BY SUPPRESSING MEMORY-RELATED ENCODING
PI -43
Yosef Same, Miriam Fishbein,
Sahar Gov, Ora Keren
and Mikhal Garni
EXTREMELY LOW DOSES OF
TETRAHYDROCANNABINOL PROTECT FROM
COGNITIVE DEFICITS AND INDUCE LONG-LASTING
BIOCHEMICAL CHANGES IN THE MOUSE BRAIN
PI -44
Roberto Colangeli, Ines Santolini,
Silvana Gaetani, Ferdinando
Nicoletti, Richard Ngomba
and Vincenzo Cuomo
ALTERATIONS OF CB1 mRNA EXPRESSION
IN STARGAZER MUTANT MICE AND IN
PENTYLENETETRAZOLE-INDUCED SPIKE
AND WAVE DISCHARGES IN RATS
Pl-45
Alex Naftaly, Shimon Rabichev,
Orit Karminsky, Jiirg Gertsch,
Ken Mackie Tibor Harkany,
Ruth A. Ross, Ester Fride
and Sharon Anavi-Goffer
REDUCED EXPLORATION BEHAVIOUR BY NMDA
ANTAGONIST IS REVERSED BY HU-308
PI -46
Fabricio A. Moreira, Luciano R.
Vilela, Daniel C. Medeiros,
Gustavo H. Rezende, Antonio C.
Oliveira and Marcio F. Moraes
EFFECTS OF CANNABINOIDS AND ENDOCANNABINOID-
HYDROLYSIS INHIBITION ON PENTYLENETETRAZOLE-
INDUCED SEIZURES AND
ELECTROENCEPHALOGRAPHIC ACTIVITY
Pl-47
Floor Remmers, Sabine Ruehle,
Hector Romo-Parra, Federico
Massa, Melanie Wickert, Nadine
Kaiser, Giovanni Marsicano,
Hans-Christian Pape
and Beat Lutz
ENDOCANNABINOID SIGNALLING AND
FEAR EXTINCTION IN MOUSE LINES FOR
GLUTAMATERGIC AND GABAERGIC-SPECIFIC
RESCUE FROM CB1 RECEPTOR DEFICIENCY
PI -48
Vanessa Enk, Martin Haring,
Floor Remmers, Sabine Riihle
and Beat Lutz
EXPLORATORY BEHAVIOR AND RESPONSE TO THC IN
MOUSE LINES FOR GLUTAMATERGIC AND GABAERGIC-
SPECIFIC RESCUE FROM CB1 RECEPTOR DEFICIENCY
PI -49
Topic D. cannabis
Donald P. Land
and Kymron B. deCesare
CANNABIS IN (NORTHERN) CALIFORNIA,
2011-2012: STATISTICS AND TRENDS FROM
THOUSANDS OF INDIVIDUAL SAMPLES TESTED
FOR 15 CANNABINOIDS AND 8 TERPENOIDS
Pl-50
Adam Ogden, Andrew Higham
and Karen Wright
IMPORTANCE OF REFERENCE GENES IN
VALIDATING THE EFFECTS OF CANNABIDIOL
ON FIBROTIC PROCESSES
Pl-51
Zlatko Mehmedic, Mohamed M.
Radwan, Suman Chandra,
Mudasir Tantry, Afeef S. Husni,
Stephen Cutler, Ikhlas A. Khan
and Mahmoud A. hlsohly
VOLATILE OIL FROM HIGH POTENCY
CANNABIS SATIVA WITH IN VITRO BINDING
AFFINITY FOR HUMAN CANNABINOID RECEPTORS
Pl-52
Patrik Roser, Silke Lissek, Martin
Tegenthoff, Volkmar Nicolas,
Georg Juckel and Martin Briine
ALTERATIONS OF THEORY OF MIND NETWORK
ACTIVATION IN CHRONIC CANNABIS USERS
Pl-53
Kristen Courtney
CANNABIS USE IN PREGNANCY AND BREASTFEEDING
Pl-54
POSTER SESSION 2: TOPICS E - G
DAY 2, TUESDAY, JULY 24 th : 16:00 - 18:00
Topic E. receptor Signaling
M. Genedy,
N. Hoenig, M. Youseffi
and M.C.T. Denyer
EFFECT OF CANNABINOIDS (WIN55,212-2)
IN ACCELERATION OF WOUND HEALING
IN BONE CELL MONOLAYER
P2-1
M. Genedy, M. Youseffi
and M.C.T. Denyer
EFFECT OF CB2 SELECTIVE AGONIST ON
WOUNDED BONE CELL MONOLAYERS
P2-2
A. Abdeldayem, M. Yousseffi
and M.C.T. Denyer
THE EFFECT OF DIFFERENT CONCENTRATIONS OF
CANNABINOID (WIN 55,212-2) ON WOUND HEALING
OF CHONDROCYTE MONOLAYER
P2-3
A. Abdeldayem, M. Yousseffi
and M.C.T. Denyer
THE EFFECT OF DIFFERENT CONCENTRATIONS
OF THE SYNTHETIC CANNABINOIDS WIN 55,212-2,
URB602 AND HU-308 ON WOUND HEALING OF
CHONDROCYTE MONOLAYER
P2-4
Philip W. Brownjohn
and John C. Ashton
PROTEOMIC IDENTIFICATION OF THE RAT
CANNABINOID CB2 RECEPTOR USING MASS
SPECTROMETRY AND IMMUNOBLOTTING
P2-5
Dina Navia-Paldanius,
Niina Aaltonen, Marko
Lehtonen, Ulrike Taschler,
Franz P. Radner,
Robert Zimmermann
and Jarmo T. Laitinen
BRAIN REGIONAL DESENSITIZATION OF CANNABINOID
CB1 RECEPTOR SIGNALING IN MICE WITH GLOBAL
GENETIC KNOCKOUT OF MONOACYLGLYCEROL LIPASE
P2-6
Pekkala S, Wiklund P, Hulmi JJ,
Marjomaki V, Alen M,
Pollanen E, Fachada V, Mero AA
and Cheng S
CANNABINOID RECEPTOR 1 REGULATES
PROTEIN SYNTHESIS AND TRANSLATION
IN HUMAN SKELETAL MUSCLE
P2-7
Jahan P. Marcu, Steven N. Popoff
and Mary E. Abood
CB1 AND CB2 ANTAGONIST
SIGNALING IN OSTEOBLASTS
P2-8
Gemma L. Baillie, Roger G.
Pertwee and Ruth A. Ross
SIGNALLING TRAFFICKING AT THE
CANNABINOID CB1 RECEPTOR BY THE CB1
ALLOSTERIC MODULATOR, ORG 27569
P2-9
William A. Devane, David L.
Stevens, David P. Finn, Ntsang
M. Nebane, Zhao-Hui Song,
David Peters, Duncan Crawford,
J. Michael Walker, Benjamin
Applegate, John M. Kennish,
Michael P. Cassidy, Dana E.
Selley, Anne Zimmer, Andreas
Zimmer and William L. Dewey
LEELAMINE, A NOVEL DITERPENE, EXHIBITS
CANNABIMIMETIC EFFECTS IN CB1 RECEPTOR
KNOCKOUT MICE
P2-10
Richard S. Priestley,
Stephen P.H. Alexander
and David A. Kendall
EARLY AND LATE PHASE ERK RESPONSES REVEAL
A NOVEL FUNCTIONALLY SELECTIVE AGONIST PROFILE
AT CANNABINOID TYPE 1 RECEPTORS
P2-11
Chris S. Breivogel
and Manan Vaghela
BETA-ARRESTIN1 MEDIATION OF
THE EFFECTS OF CANNABINOID LIGANDS
P2-12
Alex Straiker, Laura Pardon,
Lisa Walter, Nephi Stella
and Suresh Viswanathan
EVIDENCE FOR A FUNCTIONAL ROLE
OF CB1 CANNABINOID RECEPTORS IN THE
MAMMALIAN CONE PATHWAY
P2-13
Linda Console-Bram, Eugen
Brailoiu, Cristina Brailoiu
and Mary E. Abood
CALCIUM MOBILIZATION AND MAPK
ACTIVITY VIA GPR18
P2-14
Jagjeet Singh, Diane Lynch,
Zhao-Hui Song
and Patricia H. Reggio
THE IMPORTANCE OF THE CB2 HOMODIMER TO THE
CB2 CATALYZED ACTIVATION OF Gi PROTEIN
P2-15
Lysann Palkowitsch,
Julia Benkert, Sebastian Rading,
Barbara Mopps
and Meliha Karsak
TCTEX1 -
A PUTATIVE CB2 RECEPTOR REGULATING PROTEIN
P2-16
Natalia Murataeva, Ken Mackie
and Alex Straiker
THE CB2-PREFERRING AGONIST JWH015 ALSO
POTENTLY AND EFFICACIOUSLY ACTIVATES
r^RI TM A T TT A PTTf T^TTPPOf^ A AA P A T MPT TPOMQ
LDl UN /\U 1/\1 IIV^. rill 1 LJ^/\1V11 /\L INI EUIvL-'inD
P2-17
Jennifer L. Hollis
and Heather B. Bradshaw
PUTATIVE CANNABINOID RECEPTOR GPR18 IS
PRODUCED IN RAW 264.7 MACROPHAGE CELLS
P2-18
Kristin Hines
and Heather Bradshaw
N-ARACHIDONOYL GLYCINE ACTIVATION OF p44/42
MAPK IN HUMAN ENDOMETRIAL CARCINOMA CELLS
P2-19
Somnath Mukhopadhyay,
Genevieve Laroche,
Vladimir Poltoratsky
and David Siderovski
TUNING CANNABINOID RECEPTOR
SIGNALING BY RGS12 (REGULATORS OF
G-PROTEIN SIGNALING) PROTEIN
P2-20
Topic F. Drug Addiction
A. Llorente-Berzal,
E. Puighermanal, A. Burokas,
A. Ozaita, R. Maldonado,
E.M. Marco and M.P. Viveros
SEX DEPENDENT BEHAVIORAL AND MOLECULAR
EFFECTS OF THC AND MDMA IN AN ANIMAL MODEL
OF ADOLESCENT DRUG CONSUMPTION
P2-21
Lile JA, Kelly TH, Stinchcomb
AL, Charnigo RJ, Forester EB,
Hudson DA, Neltner MJ
and Hays LR
PHARMACOKINETIC AND PHARMACODYNAMIC
EFFECTS OF SUPRA-THERAPEUTIC A 9 -THC
DOSES IN CANNABIS USERS
P2-22
Amir Englund, Paul Morrison,
Judith Nottage, Dominic Hague,
Fergus Kane, Stefania
Bonaccorso, James Stone, Avi
Reichenberg, Rudolf Brenneisen,
David Holt, Amanda Fielding,
Dominic ffytche, Robin Murray
and Shitij Kapur
CANNABIDIOL INHIBITS THC-ELICITED PSYCHOSIS
AND MEMORY IMPAIRMENTS IN HUMANS
P2-23
Salvatore Lecca, Antonio
Luchicchi, Marta De Felice
and Marco Pistis
MATERNAL IMMUNE ACTIVATION DISRUPTS THE
FUNCTIONALITY OF MESOLIMBIC DOPAMINE
NEURONS: INVOLVEMENT OF CANNABINOIDS
P2-24
Beata Bystrowska, Karolina
Wydra, Agata Suder, Irena
Smaga and Malgorzata Filip
CHANGES IN CONCENTRATION OF
ENDOCANNABINOIDS AND N-ACYL ETHANOLAMIDES
IN BRAIN STRUCTURES OF RATS UNDERWENT COCAINE
SELF-ADMINISTRATION AND ITS WITHDRAWAL
P2-25
Iain S. McGregor, Alex Wong,
Kong M. Li,
Jonathon C. Arnold
and Wendy Swift
CANNABIS POTENCY IN NEW SOUTH
WALES AUSTRALIA: AN ANALYSIS OF POLICE
SEIZED STREET SAMPLES
P2-26
Thomas Gamage, Divya Ramesh,
Rehab Abdullah,
Micah J. Niphakis, Ben Cravatt
and Aron Lichtman
DUAL FAAH/MAGL INHIBITION ATTENUATES
SOMATIC SIGNS OF SPONTANEOUS MORPHINE
WITHDRAWAL IN ICR MICE
P2-27
Matthew F. Lazenka,
Eric J. Nestler, Dana E. Selley
and Laura J. Sim-Selley
ROLE OF AFOSB IN CB1R DESENSITIZATION IN THE
BASAL GANGLIA
P2-28
Sofia B. Gustafsson
and Stig O. P. Jacobsson
EFFECTS OF CANNABINOIDS ON THE DEVELOPMENT
OF CHICK EMBRYOS IN OVO
P2-29
Fabiana Piscitelli, Aron
Lichtman, Laura Sim-Selley,
Robert Hamm, Tiziana Bisogno,
Vincenzo Di Marzo
and Raphael Mechoulam
TARGETED LIPIDOMICS PROFILING OF INJURED
RAT BRAIN: POSSIBLE IMPLICATIONS FOR
NICOTINE DEPENDENCE
P2-30
Emmanuel S. Onaivi,
Hiroki Ishiguro, Alvaro Llorente-
Berzal, Maria-P Viveros
and George R. Uhl
CANNABINOID RECEPTORS: GENE STRUCTURES, SNPS,
CNVS, CPG ISLANDS MICRORNA REGULATION AND
VARIATION IN NEUROPSYCHIATRY DISORDERS
P2-31
Bela Szabo, Volker Auwarter,
Mario Lederer, Stefan Kneisel
and Maren Hermanns-Clausen
ACUTE INTOXICATIONS FOLLOWING
CONSUMPTION OF HERBAL PRODUCTS
CONTAINING SYNTHETIC CANNABINOIDS
P2-32
TOPIC G. CANCER / IMMUNOLOGY
Torsten Lowin, Angelika Graber,
Elena Neumann
and Rainer H. Straub
ANAND AMIDE ATTENUATES THE
INFLAMMATORY PHENOTYPE OF RHEUMATOID
ARTHRITIS SYNOVIAL FIBROBLASTS BY
ACTIVATING MULTIPLE RECEPTOR PATHWAYS
P2-33
Torsten Lowin, Wentao Zhu,
Katja Dettmer, Elena Neumann
and Rainer H. Straub
CORTISOL-INDUCED ADHESION OF
SYNOVIAL FIBROBLASTS IS MEDIATED
BY THE ENDOCANNABINOID SYSTEM
P2-34
Wook Kim, Qizong Lao,
Yu-Kyong Shin, Olga D. Carlson,
Eun Kyung Lee, Myriam
Gorospe, Rohit N. Kulkarni
and Josephine M. Egan
CANNABINOIDS INDUCE PANCREATIC
BETA-CELL DEATH BY DIRECTLY INHIBITING
INSULIN RECEPTOR ACTIVATION
P2-35
Daniel Kerr, Brendan Harhen,
David P. Finn
and Michelle Roche
PHARMACOLOGICAL INHIBITION OF
MONOACYLGLYCEROL LIPASE ATTENUATES
LPS-INDUCED INCREASES IN CYTOKINE EXPRESSION
IN THE RAT FRONTAL CORTEX AND PLASMA:
P2-36
Daniel Roskowski,
Douglas McHugh, Siyun Xie
and Heather B. Bradshaw
N-ARACHIDONOYL GLYCINE REGULATES THE
PHENOTYPIC MORPHOLOGY OF BV-2 MICROGLIA
P2-37
Evan Jameyfield, Siham
Raboune, Douglas McHugh
anu nearner d. Drausnaw
NOVEL ENDOGENOUS N-ACYL AMIDES INDUCE
CALCIUM MOBILIZATION IN BV-2 MICROGLIA
P2-38
Douglas McHugh, Jeremy Page
and Heather B. Bradshaw
N-ARACHIDONOYL GLYCINE AND A 9 -THC REGULATE
THE CYTOKINE PRODUCTION OF BV-2 MICROGLIA
P2-39
Seok-Woo Park
and Myung-Whun Sung
CANNABINOID RECEPTOR-INDEPENDENT
ANTIPROLIFERATIVE EFFECT OF DOCOSAHEXAENOYL
ETHAN OLAMIDE IN HEAD AND NECK SQUAMOUS
CELL CARCINOMA CELLS
P2-40
Benjamin Gennequin,
David-Marian Otte, Katrin
Zimmermann, Anne Zimmer
and Andreas Zimmer
FUNCTIONAL ANALYSIS OF THE HUMAN CB2
RECEPTOR VARIANTS
P2-41
Luciano De Petrocellis,
Alessia Ligresti, Aniello Schiano
Moriello, Roberta Verde,
Pierangelo Orlando,
Colin G. Stott
and Vincenzo Di Marzo
CANNABINOIDS IN PROSTATE CANCER: AN UPDATE
P2-42
Svenja S. Ternes, Judith Alferink
and Andreas Zimmer
REGULATION OF INFLAMMATORY PROCESSES
BY THE ENDOCANNABINOID SYSTEM
P2-43
Christeene Haj,
Percy F. Sumariwalla, Natalya
Kogan, Zhanna Yektin,
Marc Feldmann, Raphael
Mechoulam and Ruth Gallily
NOVEL CANNABIDIOL DERIVATIVES AND
THEIR USE AS ANTI-INFLAMMATORY AGENTS
P2-44
Toguri, J.T., Szczesniak, A.M.,
Zhou, J., Lehmann, C.
and Kelly, M.E.M
CANNABINOID MODULATION OF LEUKOCYTE-
ENDOTHELIAL INTERACTIONS IN AN ENDOTOXIN-
INDUCED UVEITIS MODEL
P2-45
Anna-Maria Szczesniak
and Melanie E.M. Kelly
THE ROLE OF CANNABINOID RECEPTOR 2 IN THE
EXPERIMENTAL AUTOIMMUNE UVEORETINITIS
P2-46
Neta Rimmerman, Ana Juknat,
Ewa Kozela, Ziv Porat, Danya
Ben-Hail, Varda Shoshan-
Barmatz and Zvi Vogel
CANNABIDIOL AFFECTS MITOCHONDRIAL
TARGETS IN BV-2 MICROGLIAL CELLS
P2-47
Jocelijn Meijerink, Mieke Poland,
Michiel Balvers, Zheng Wang,
Jvalini Dwarkasing
and Renger F. Witkamp
FISHING FOR CANNABINOIDS FROM FISH; IMMUNE-
MODULATORY MECHANISMS OF AMIDES DERIVED
FROM N-3 FATTY ACIDS
P2-48
Tara Macpherson, John
Westwick and Karen Wright
CANNABIDIOL AFFECTS CELLULAR
BIOENERGETICS IN COLON CANCER
P2-49
Amy G. Eubanks, Cameron A.
Tull, Amber E. Prescott, John R.
Sims, Emily R. Coffman, Whitley
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Nolan J. West, Vikki K. Bennett,
Cara L. McKinney, Jessica R.
Winston, Larry J. Suva, Robert J.
Griffin and Lori L. Hensley
ANTT-TTTMOR FFFFCTS OF ATT IT FMTC ACTD ON
THE EWING'S SARCOMA FAMILY OF TUMORS
P2-50
A.M. Wasik, S. Almestrand,
F. Zong, P. Andersson, E. Kimby,
B. Christensson and B. Sander
MAPPING OF THE ENDOCANNABINOID SYSTEM
IN MANTLE CELL LYMPHOMA
P2-51
Mohd W. Nasser, Zahida Qamri,
Konstantin Shilo
and Ramesh K. Ganju
CANNABINOID RECEPTOR CB2 CROSSTALK WITH
CHEMOKINE RECEPTOR CXCR4 TO MODULATE BREAST
CANCER GROWTH AND METASTASIS
P2-52
Somnath Mukhopadhyay,
Shalini Jha and Victoria Jones
CB2 RECEPTOR-MEDIATED REGULATION OF I2PP2A
(INHIBITOR 2 OF PROTEIN PHOSPHATASE 2A): A NEW
TARGET FOR PROSTATE CANCER TREATMENT
P2-53
Benjamin S. Harvey
and Scott D. Smid
EFFECTS OF PRO-INFLAMMATORY CYTOKINES
AND CANNABINOIDS ON INTESTINAL
EPITHELIAL PERMEABILITY
P2-54
June Penman, Alana J. Burns
and Andrew J. Irving
L-a-LYSOPHOSPHATIDYLINOSITOL AND AM251
PROMOTE CYTOSKELETAL REORGANISATION IN
CANCER CELL LINES THAT EXPRESS GPR55
P2-55
POSTER SESSION 3: TOPICS H - J
DAY 3, WEDNESDAY, JULY 25 th : 10:45 - 12:45
Topic h. Ligand Development
Daniel J. Hermanson,
Nolan D. Hartley, Sachin Patel
and Lawrence J. Marnett
DEVELOPMENT OF LM-4131, A SUBSTRATE-SELECTIVE
INHIBITOR OF CYCLOOXYGENASE-2
P3-1
Pritesh Kumar, Akhilesh Kumar
and Zhao-Hui Song
STRUCTURE-ACTIVITY RELATIONSHIPS OF LIGANDS
FOR GPR119 - A GPCR THAT IS RELATED TO
CANNABINOID RECEPTORS
P3-2
Jayendra Z. Patel, Teija Parkkari
and Tapio Nevalainen
3,4-DISUBSTITUTED THIADIAZOLES AS
FAAH AND/OR MGL INHIBITORS
P3-3
Andrea Chicca, Janine Marazzi,
Simon Nicolussi
and Jiirg Gertsch
EVIDENCE FOR A BIDIRECTIONAL ENDOCANNABINOID
TRANSPORT ACROSS CELL MEMBRANES AND
IDENTIFICATION OF SELECTIVE INHIBITORS
P3-4
Roger Slavik, Daniel Bieri,
Konstantin Drandarov, Adrienne
Miiller, Stefanie Kramer, Roger
Schibli, Simon M. Ametamey
and Linjing Mu
SYNTHESIS AND EVALUATION OF NOVEL
CANNABINOID TYPE 2 RECEPTOR TRACERS
FOR PET IMAGING
P3-5
Sari Yrjola, Tuomo Kalliokoski,
Teija Parkkari, Tuomo Laitinen,
Antti Poso and Tapio Nevalainen
2,4,6-TRISUBSTITUTED 1,3,5-TRIAZINES
AS SELECTIVE CB2 AGONISTS
P3-6
Sara Del Carlo, Giuseppe
Saccomanni, Clementina
Manera, Giancarlo Pascali,
Francesca Castelli, Alessia
Ligresti, Vincenzo Di Marzo,
Marco Macchia
and Piero A. Salvadori
[18F]-LABELED HETEROCYCLIC DERIVATIVES
FOR PET IMAGING OF CANNABINOID CB2 RECEPTOR
P3-7
Barbara Bosier,
Giulio G. Muccioli, Eric Stern
and Didier M. Lambert
4-OXO-l,4-DIHYDROQUINOLINE-3-CARBOXAMIDE
DERIVATIVES AS FUNCTIONAL SELECTIVE LIGANDS AT
THE CB2 CANNABINOID RECEPTOR
P3-8
Reem Smoum, Saja Baraghithy,
Aviva Breuer, Malka Attar-
Namdar, Raphael Mechoulam
and Itai Bab
NOVEL CB2 AGONIST HU-433 MODULATES SKELETAL
REMODELING AND BONE MASS
P3-9
Cristina Fernandez-Fernandez,
Laura Hernandez-Folgado,
Nadine Jagerovic, Maria Gomez-
Canas, Maria Gomez-Ruiz, Javier
Fernandez-Ruiz and Pilar Goya
SYNTHESIS AND EVALUATION OF NOVEL
CB2 CANNABINOID LIGANDS
P3-10
Jiirgen Fingerle, Uwe Grether,
Atsushi Kimbara, Matthias
Nettekoven, Mark Rogers-Evans,
Stephan Rover, Tanja Schulz-
Gasch, Christoph Ullmer
and Franz Schuler
INITIAL HTS HIT OPTIMIZATION: NOVEL, HIGHLY
POTENT AND SELECTIVE CB2 AGONISTS
P3-11
Valentina Lucchesi, Haleli Sharir,
Giuseppe Saccomanni, Alessia
Ligresti, Vincenzo Di Marzo,
Marco Macchia, Mary E. Abood
and Clementina Manera
INVESTIGATION ON l,8-NAPHTHYRIDIN-2(lH)-ON-3-
CARBOXAMIDES A CLASS OF POTENT CB2 SELECTIVE
CANNABINOID RECEPTOR LIGANDS: SYNTHESIS,
STRUCTURE- ACTIVITY RELATIONSHIPS AND
FUNCTIONAL ACTIVITY
P3-12
Herbert H. Seltzman,
Rangan Maitra, Patricia Reggio,
Daniel Wesley, Joseph Tarn
and George Kunos
IN VIVO METABOLIC EFFECTS OF PIMSR,
A CANNABINOID CB1 RECEPTOR
NEUTRAL ANTAGONIST
P3-13
Rangan Maitra, Alan Fulp,
Katherine Bortoff, Herbert
Seltzman, Yanan Zhang,
Timothy Fennell, James Mathews
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TOWARDS RATIONAL DEVELOPMENT
OF PERIPHERALLY SELECTIVE ANTAGONISTS
OF CANNABINOID RECEPTOR 1
P3-14
Lirong Wang, Junmei Wang,
Zhaojun Xie, Chao Ma,
Kyaw Myint and Xiang-Qun Xie
CLOUD COMPUTING WEBSERVER
FOR CANNABINOID RESEARCH
P3-15
James D Wakefield, Kristie A
Sykes, Nisha Perez, Stacy D
Arnett, Vasu Sethuraman,
Christopher M Graul, James P
Pearson, G Todd Milne, Albert
Profy, Robert W Busby
and Kamlesh P Vyas
PHARMACOKINETICS AND PHARMACODYNAMICS OF
A POTENT, SELECTIVE AND ORALLY BIO AVAILABLE
FAAH INHIBITOR, MM-433593 IN SPRAGUE-DAWLEY
RATS, CYNOMOLGUS MONKEYS AND HUMAN
P3-16
Ming-Shiu Hung, Kak-Shan Shia,
Teng-Kang Yeh, Jen-Shin Song,
Chun-Ping Chang, Yinchiu Lin,
Pei-Chuan Chen, Wen-Chy
Hsiao and Yu-Sheng Chao
A NOVEL PERIPHERAL CB1 ANTAGONIST
REDUCES FOOD INTAKE AND EXHIBITS EFFICACY IN
IMPROVING ADIPOSITY AND INSULIN RESISTANCE
P3-17
Paolo Lazari, Gabriele
Murineddu, Ilaria Manca,
Giovanni Loriga
and Gerard Aime Pinna
MYRTANIL SUBSTITUENT IN 3 POSITION OF PIRAZOLE
RING DETERMINES CB1 AGONISM OF NOVEL 4,5-
DIHYDROBENZO-OXA-CYCLOHEPTAPYRAZOLE
CANNABINOIDS
P3-18
Mario van der Stelt
DISCOVERY AND OPTIMIZATION OF l-(4-(PYRIDIN-2-
YL)BENZYL) IMIDAZOLIDINE-2,4-DIONE DERIVATIVES
AS A NOVEL CLASS OF SELECTIVE CANNABINOID
CB2 RECEPTOR AGONISTS
P3-19
TOPIC I. ENDOCANNABINOIDS & ENZYMES
Tatsuya Tai, Kazuhito Tsuboi,
Toru Uyama, Kim Masuda,
Benjamin F. Cravatt, Hitoshi
Houchi and Natsuo Ueda
STIMULATORY EFFECTS OF PHOSPHOLIPIDS AND
DIHYDROLIPOIC ACID ON N-ACYLETHANOLAMINE-
HYDROLYZING ACID AMIDASE (NAAA)
P3-20
Jayendra Z. Patel, Teija Parkkari,
Susanna M. Saario
and Tapio Nevalainen
NOVEL OXADIAZOLONE ANALOGUES
AS FAAH AND/OR MGL INHIBITORS
P3-21
Mariateresa Cipriano, Jonas
Eriksson, Emmelie Bjorklund,
Alka Marwaha, Anders
Lindgren, Per-Anders Enquist,
Mikael Elofsson
and Christopher J. Fowler
NOVEL INHIBITORS OF MONOACYLGLYCEROL LIPASE
P3-22
Mauro Maccarrone, Almerinda
Di Venere, Enrico Dainese,
Filomena Fezza, Beatrice Clotilde
Angelucci, Nicola Rosato,
Benjamin F. Cravatt, Alessandro
Finazzi-Agro and Giampiero Mei
HIDDEN DIFFERENCES BETWEEN RAT AND
HUMAN FATTY ACID AMIDE HYDROLASES
P3-23
Redmond W.J., Gu L.,
Mclntyre P. and Connor M
DETERMINANTS OF FATTY ACID ACTIVATION OF
THE PRONOCICEPTIVE ION CHANNEL TRPA1
P3-24
Ulrike Thieme, Matthias
Feuerecker, Daniela Hauer, Alex
Salam, Detlef Thieme, Alexander
Chouker and Gustav Schelling
CHANGES IN CIRCULATING ENDOCANNABINOIDS
AND N-ACYLETHANOLAMINES DURING
OVERWINTERING AT CONCORIA RESEARCH
STATION IN CONTINENTAL ANTARCTICA
P3-25
Cyrill Hornuss, Daniela Hauer,
Patrizia Campolongo, Isabel
Briegel, Christian C. Apfel
and Gustav Schelling
GENERAL ANESTHESIA WITH PROPOFOL INFLUENCES
CIRCULATING ENDOCANNABINOIDS AND
N-ACYLETHANOLAMINES: A STUDY IN VOLUNTEERS
P3-26
Kazuhito Tsuboi, Yumiko
Yamano, Yuki Hozaki, Kiyohiro
Takahashi, Xing-Hua Jin,
Akimori Wada and Natsuo Ueda
LIPOPHILIC AMINES AS INHIBITORS OF
N-ACYLETHANOLAMINE-HYDROLYZING ACID
AMIDASE (NAAA)
P3-27
Kazuhito Tsuboi, Yasuo
Okamoto, Natsuki Ikematsu,
Manami Inoue,
Yoshibumi Shimizu, Toru
Uyama, Dale G. Deutsch,
Akira Tokumura,
and Natsuo Ueda
BIOSYNTHETIC PATHWAYS OF
N-ACYLETHANOLAMINES FROM
N-ACYLATED PLASMALOGEN PHOSPHOLIPID
P3-28
Michiel G.J. Balvers,
Renger F. Witkamp
and Kitty CM. Verhoeckx
FREE AND ESTERIFIED N-ACYL ETHANOLAMINES
IN PLASMA AND BLOOD CELLS: EVIDENCE FOR
PREVIOUSLY IGNORED POOLS OF ESTERIFIED NAEs
P3-29
A. Martella, C. Silvestri,
O. Carnevali and V. Di Marzo
CHARACTERIZATION OF THE ENDOCANNABINOID
SYSTEM DURING ZEBRAFISH (DANIO RERIO)
EMBRYOGENESIS AND POSSIBLE DRUG
SCREENING APPLICATIONS
P3-30
Niina Aaltonen, Casandra Riera
Ribas, Marko Lehtonen,
Juha Savinainen
and Jarmo T. Laitinen
BRAIN REGIONAL CANNABINOID CB1 RECEPTOR
SIGNALLING AND ALTERNATIVE ENZYMATIC
PATHWAYS FOR 2-ARACHIDONOYLGLYCEROL
GENERATION IN BRAIN SECTIONS OF DAGL-ALPHA
AND DAGL-BETA DEFICIENT MICE
P3-31
Rebecca Henry, Daniel Kerr,
David P. Finn
and Michelle Roche
TLR-3 MEDIATED CYTOKINE EXPRESSION IN THE
RAT HIPPOCAMPUS IS ALTERED FOLLOWING
PHARMACOLOGICAL INHIBITION OF FAAH
P3-32
Collin B. Merrill, Michael
McNeil, Ryan C. Williamson
and Jeffrey G. Edwards
IDENTIFICATION OF MRNA FOR ENDOCANNABINOID
BIOSYNTHETIC ENZYMES WITHIN HIPPOCAMPAL
PYRAMIDAL CELLS AND CA1 STRATUM RADIATUM
TTV ITFTl TV TFT ' 1 1 /""*v N T f T TTT~P"\ /Til - ' C T TCTTV T / — > /~~\T T A TV ITTT A TTT f F
INTERNEURON SUBTYPES USING QUANTITATIVE
REAL-TIME PCR
P3-33
Carina E. P. Kozmus, Vojko
Berce and Uros Potocnik
CNR2 AND ABHD4 GENE EXPRESSION IS
UP-REGULATED IN ASTHMA PATIENTS
P3-34
Alex Straiker, Sherry Shu-jung
Hu, Jacqueline Blankman,
Benjamin F. Cravatt
and Ken Mackie
DISTRIBUTION OF ABHD12 PROTEIN IN MURINE BRAIN
P3-35
Elizabeth Sabens Liedhegner,
Kara Stuhr and Cecilia Hillard
REGULATION OF ENDOCANNABINOID
LEVELS BY STEROL CARRIER PROTEIN 2
P3-36
TOPIC J. PAIN
Miriam Schneider, Peggy
Schneider, Christian Schmahl,
Rainer Spanagel
and Martin Bohus
SOCIAL PAIN AND THE ENDOCANNABINOID SYSTEM:
ADOLESCENT PEER-REJECTION PERSISTENTLY
ALTERS PAIN PERCEPTION AND CB1 RECEPTOR
EXPRESSION IN FEMALE RATS
P3-37
Jordyn M. Stuart, Julie Wiesler,
Amanda Ellis, Linda Watkins,
and Heather B. Bradshaw
ENDOGENOUS CANNABINOIDS AND RELATED N-ACYL
AMIDES ARE UP AND DOWN-REGULATED IN A SPINAL
CORD INJURY MODEL OF NEUROPATHIC PAIN
P3-38
Brandon P Rhodes, Jordyn M.
Stuart, Siham Raboune
and Heather B. Bradshaw
LEVELS OF ENDOCANNABINOIDS AND RELATED
N-ACYL AMIDES CHANGE IN THE CEREBELLUM,
MIDBRAIN, BRAINSTEM AND THALAMUS IN A MODEL
OF ACUTE PERIPHERAL INFLAMMATION
P3-39
Sara M. Takacs, Jordyn M. Stuart,
Siham Raboune
and Heather B. Bradshaw
PERIPHERAL INFLAMMATION DRIVES CHANGES IN
N-ACYL AMIDES IN THE STRIATUM AND HIPPOCAMPUS
P3-40
Neil J. Poloso, Jenny W. Wang,
Elaine Tang
and David F. Woodward
CHARACTERIZATION OF A MODEL OF
OCULAR PAIN/DISCOMFORT WITH RESPECT
TO CYCLO-OXYGENASE AND PROSTANOID
RFCFPTOR TNVOT VFMFNT
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P3-41
V.S. Seybold, L.G. Coicou,
D. Piomelli and LA. Khasabova
ACTIVATION OF PPARa IN DORSAL ROOT
GANGLION NEURONS MODULATES NOCICEPTION
AND REDUCES TUMOR PAIN IN MICE
P3-42
Natalia Malek, Michal
Korostynski, Barbara Przewlocka
and Katarzyna Starowicz
NERVE INJURY-INDUCED MOLECULAR CHANGES:
ROLE OF THE ENDOCANNABINOID
AND ENDOVANILLOID SYSTEMS
P3-43
Sara Jane Ward,
Sean D. McAllister,
Harshini Neelakantan
and Ellen A. Walker
PACLIT AXEL-INDUCED NEUROTOXICITY:
EFFICACY AND SAFETY OF CANNABIDIOL
AS A NOVEL TREATMENT STRATEGY
P3-44
Liting Deng, Josee Guindon, Ken
Mackie, Fletcher White, Ganesh
Thakur, Alexandras Makriyannis
and Andrea G. Hohmann
SELECTIVE ACTIVATION OF CANNABINOID
CB2 RECEPTORS SUPPRESSES CHEMOTHERAPY-
INDUCED NEUROPATHY INDEPENDENT OF
CB1 OR CXCR4 RECEPTOR SIGNALING
P3-45
Weredeselam M. Olango,
Michelle Roche
and David P. Finn
PHARMACOLOGICAL MODULATION OF THE
ENDOCANNABINOID SYSTEM IN TWO RAT STRAINS
DIFFERING IN NOCICEPTIVE RESPONSIVITY:
BEHAVIOURAL EFFECTS AND RVM ZIF268 EXPRESSION
P3-46
Bright Okine, Weredeselam M.
Olango, Brendan Harhen,
Michelle Roche
and David P. Finn
CHARACTERISATION OF THE
ENDOCANNABINOID SYSTEM WITHIN THE
DESCENDING PAIN PATHWAY OF TWO RAT
STRAINS DIFFERING IN NOCICEPTIVE RESPONSIVITY
P3-47
Padmanabha V. Kattamuri,
Rebecca Salmonsen, Catherine
McQuain, Sumner Burstein
and Guigen Li
ASYMMETRIC SYNTHESIS OF NOVEL N-(l-PHENYL-2,3-
DIHYDROXYPROPYL) ARACHIDONYLAMIDES
AND EVALUATION OF THEIR ANTI-
INFLAMMATORY ACTIVITY
P3-48
Ermelinda Lomazzo, Raissa
Lerner, Claudia Schwitter
and Beat Lutz
THE ENDOCANNABINOID SYSTEM AND
STRESS-MEDIATED ENHANCEMENT OF
PAIN SUSCEPTIBILITY IN MICE
P3-49
Enza Palazzo, Vito de Novellis,
Livio Luongo, Francesca Guida,
and Sabatino Maione
INTERACTION BETWEEN CANNABINOID AND
METABOTROPIC GLUTAMATE RECEPTORS IN THE
PERIAQUEDUCTAL GRAY-ROSTRAL VENTROMEDIAL
MEDULLA PATHWAY IN NEUROPATHIC RAT
P3-50
Sudeshna Ghosh, Laura E. Wise,
Rehab A. Abdulla, Micah J.
Niphakis, Benjamin F. Cravatt
and Aron H. Lichtman
COMBINED INHIBITION OF MAGL AND
FAAH SUPPRESSES EDEMA AND PRODUCES
AUGMENTED ANTI-ALLODYNIC EFFECTS
IN THE CARRAGEEN AN MOUSE MODEL
P3-51
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